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Article

Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.

Nature structural & molecular biology - 1 Sept 2010

Drage Michael G, Tsai Han-Chun, Pecora Nicole D, Cheng Tan-Yun, Arida Ahmad R, Shukla Supriya, Rojas Roxana E, Seshadri Chetan, Moody D Branch, Boom W Henry, Sacchettini James C, Harding Clifford V

Abstract excerpt

Knockout of lprG results in decreased virulence of Mycobacterium tuberculosis (MTB) in mice. MTB lipoprotein LprG has TLR2 agonist activity, which is thought to be dependent on its N-terminal triacylation. Unexpectedly, here we find that nonacylated LprG retains TLR2 activity. Moreover, we show LprG association with triacylated glycolipid TLR2 agonists lipoarabinomannan, lipomannan and phosphatidylinositol...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20694006
DOI: 10.1038/nsmb.1869
PMCID: PMC2933325

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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