Article
The presence of a galactosamine substituent on the arabinogalactan of Mycobacterium tuberculosis abrogates full maturation of human peripheral blood monocyte-derived dendritic cells and increases secretion of IL-10.
Tuberculosis (Edinburgh, Scotland) - 1 Jul 2015
Wheat William H, Dhouib Rabeb, Angala Shiva K, Larrouy-Maumus Gérald, Dobos Karen, Nigou Jérôme, Spencer John S, Jackson Mary
Abstract excerpt
Slow-growing and pathogenic Mycobacterium spp. are characterized by the presence of galactosamine (GalN) that modifies the interior branched arabinosyl residues of the arabinogalactan (AG) that is a major heteropolysaccharide cell wall component. The availability of null mutants of the polyprenyl-phospho-N-acetylgalactosaminyl synthase (Rv3631, PpgS) and the (N-acetyl-) galactosaminyl transferase (Rv3779) of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.