Hypermethylation of CpG island loci of multiple tumor suppressor genes in retinoblastoma.

doi:10.1016/j.exer.2007.10.010

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Article

Hypermethylation of CpG island loci of multiple tumor suppressor genes in retinoblastoma.

Experimental eye research - 1 Feb 2008

Cohen Yoram, Merhavi-Shoham Efrat, Avraham Revital B, Frenkel Shahar, Pe'er Jacob, Goldenberg-Cohen Nitza

Abstract excerpt

Epigenetic silencing of tumor suppressor genes by methylation of discrete regions of the CpG islands is a major mechanism underlying tumorigenesis. Methylation of at least three of five specific genes may represent a distinct trait, termed the CpG island methylator phenotype (CIMP). Positive CIMP is associated with BRAF mutations. The present study sought to investigate the presence of BRAF mutations in human...

Topics

Base Sequence
CpG Islands
DNA Methylation
DNA Mutational Analysis
DNA, Neoplasm
Epigenesis, Genetic
Gene Silencing
Genes, Retinoblastoma
Genes, Tumor Suppressor
Humans
Mutation
Proto-Oncogene Proteins B-raf
Retinal Neoplasms
Retinoblastoma

Source

Open in PubMed

Identifiers

PMID: 18068703
DOI: 10.1016/j.exer.2007.10.010

Genes

BRAF
NEUROG1
DAP
RUNX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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