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Article

Hypermethylation of CpG island loci of multiple tumor suppressor genes in retinoblastoma.

Experimental eye research - 1 Feb 2008

Cohen Yoram, Merhavi-Shoham Efrat, Avraham Revital B, Frenkel Shahar, Pe'er Jacob, Goldenberg-Cohen Nitza

Abstract excerpt

Epigenetic silencing of tumor suppressor genes by methylation of discrete regions of the CpG islands is a major mechanism underlying tumorigenesis. Methylation of at least three of five specific genes may represent a distinct trait, termed the CpG island methylator phenotype (CIMP). Positive CIMP is associated with BRAF mutations. The present study sought to investigate the presence of BRAF mutations in human...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 18068703
DOI: 10.1016/j.exer.2007.10.010

Genes

BRAF
NEUROG1
DAP
RUNX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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