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Article

Clinical implications of promoter hypermethylation in RASSF1A and MGMT in retinoblastoma.

Neoplasia (New York, N.Y.) - 1 Mar 2005

Choy Kwong Wai, Lee Tom C, Cheung Kin Fai, Fan Dorothy S P, Lo Kwok Wai, Beaverson Katherine L, Abramson David H, Lam Dennis S C, Yu Christopher B O, Pang Chi Pui

Abstract excerpt

We investigated the epigenetic silencing and genetic changes of the RAS-associated domain family 1A (RASSF1A) gene and the O6-methylguanine-DNA methyltransferase (MGMT) gene in retinoblastoma. We extracted DNA from microdissected tumor and normal retina tissues of the same patient in 68 retinoblastoma cases. Promoter methylation in RASSF1A and MGMT was analyzed by methylation-specific PCR, RASSF1A sequence...

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Source

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Identifiers

PMID: 15799820
DOI: 10.1593/neo.04565
PMCID: PMC1501141

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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