Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development.

Cancer research - 15 Oct 2002

Lusher Meryl E, Lindsey Janet C, Latif Farida, Pearson Andrew D J, Ellison David W, Clifford Steven C

Abstract excerpt

Epigenetic inactivation of the RASSF1A tumor suppressor gene (TSG) at chromosome 3p21.3 was examined in medulloblastoma, the most common malignant brain tumor of childhood. Seventy-nine % (27 of 34) of primary tumors and 100% (8 of 8) of medulloblastoma cell lines displayed extensive tumor-specific DNA hypermethylation across the RASSF1A promoter-associated CpG island. Hypermethylation was associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Chromosomes, Human, Pair 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Silencing

Share to Genes, Tumor Suppressor

Share to Medulloblastoma

Share to Neoplasm Proteins

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 12384556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development.PMID 12384556Read ↗

Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia.Semantic proximity Read ↗

Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines.Semantic proximity Read ↗

Association of Epigenetic Inactivation of RASSF1A with Poor Outcome in Human NeuroblastomaSemantic proximity Read ↗

The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastomaSemantic proximity Read ↗

Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2Semantic proximity Read ↗

Clinical implications of promoter hypermethylation in RASSF1A and MGMT in retinoblastoma.Semantic proximity Read ↗

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemiasSemantic proximity Read ↗

Frequent epigenetic inactivation of the RASSF1A tumour suppressor gene in testicular tumours and distinct methylation profiles of seminoma and nonseminoma testicular germ cell tumoursSemantic proximity Read ↗

The tumor suppressor RASSF1A in human carcinogenesis: an update.Semantic proximity Read ↗

Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis.Semantic proximity Read ↗

Frequent epigenetic inactivation of RASSF1A by aberrant promoter hypermethylation in human gastric adenocarcinoma.Semantic proximity Read ↗

RASSF1A methylation indicates a poor prognosis in hepatoblastoma patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.