Article
Downregulation and aberrant promoter methylation of p16INK4A: a possible novel heritable susceptibility marker to retinoblastoma.
Journal of cellular physiology - 1 Apr 2010
Indovina Paola, Acquaviva Antonio, De Falco Giulia, Rizzo Valeria, Onnis Anna, Luzzi Anna, Giorgi Francesca, Hadjistilianou Theodora, Toti Paolo, Tomei Valentina, Pentimalli Francesca, Carugi Alessandro, Giordano Antonio
Abstract excerpt
RB loss has long been recognized as the causative genetic alteration underlying retinoblastoma but it is increasingly evident that other alterations are required for the tumor to develop. Therefore, we set out to identify additional inheritable susceptibility markers and new potential preventive and therapeutic targets for retinoblastoma. We focused on the p16INK4A tumor suppressor gene because of its possible...
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