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Article

Association of Epigenetic Inactivation of RASSF1A with Poor Outcome in Human Neuroblastoma

15 Dec 2004

Abstract excerpt

PURPOSE: To investigate the prevalence and potential clinical significance of epigenetic aberrations in neuroblastoma (NB). EXPERIMENTAL DESIGN: The methylation status of 11 genes that are frequently epigenetically inactivated in adult cancers was assayed in 13 NB cell lines. The prevalence of RASSF1A and TSP-1 methylation was also analyzed in 56 NBs and 5 ganglioneuromas by methylation-specific PCR. Associations...

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PMID: 15623630
DOI: 10.1158/1078-0432.ccr-04-1331

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