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Article

Promoter methylation status of multiple genes in uveal melanoma.

Investigative ophthalmology & visual science - 1 Oct 2007

Merhavi Efrat, Cohen Yoram, Avraham Bat Chen R, Frenkel Shahar, Chowers Itay, Pe'er Jacob, Goldenberg-Cohen Nitza

Abstract excerpt

PURPOSE: Aberrant promoter hypermethylation of CpG islands is thought to play an important role in the inactivation of tumor-suppressor genes (TSGs) in cancer. Studies of cutaneous melanoma have reported a high methylation rate for MGMT, DAPK, RAR-b2, and RASSF1A. In colon cancer, SOCS-1, IGF-2,...

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Topics

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Share to CpG Islands
Share to DNA, Neoplasm
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Genes, Neoplasm

Share to Genes, Tumor Suppressor

Share to Melanoma

Share to Uveal Neoplasms

Source

Identifiers

PMID: 17898258
DOI: 10.1167/iovs.07-0272

Genes

MGMT
NEUROG1
RUNX3
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17898258-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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