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Article

CpG Island Methylator Phenotype Is a Strong Determinant of Poor Prognosis in Neuroblastomas

1 Feb 2005

Abstract excerpt

Neuroblastoma, one of the most common pediatric solid tumors, is characterized by two extreme disease courses, spontaneous regression and life-threatening progression. Here, we conducted a genome-wide search for differences in DNA methylation that distinguish between neuroblastomas of the two types. Three CpG islands (CGI) and two groups of CGIs were found to be methylated specifically in neuroblastomas with a...

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PMID: 15705880
DOI: 10.1158/0008-5472.828.65.3

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