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Article

Epistatic interaction between the K-homology domain protein HEK2 and SIR1 at HMR and telomeres in yeast.

Journal of molecular biology - 25 Jan 2008

Denisenko Oleg, Bomsztyk Karol

Abstract excerpt

In budding yeast, telomeres, the ribosomal DNA array, and HM loci are transcriptionally silenced by chromatin complexes containing Sir proteins. Hek2, a protein containing three evolutionary conserved RNA-binding K-homology domains, was identified as a suppressor of telomeric silencing [telomeric position effect (TPE)]. To explore the mechanisms of Hek2p action in gene silencing, we examined its relationship with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18067921
DOI: 10.1016/j.jmb.2007.11.001
PMCID: PMC2367324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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