Silencing at Drosophila telomeres: nuclear organization and chromatin structure play critical roles.

doi:10.1093/emboj/18.13.3724

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Article

Silencing at Drosophila telomeres: nuclear organization and chromatin structure play critical roles.

The EMBO journal - 1 Jul 1999

Cryderman D E, Morris E J, Biessmann H, Elgin S C, Wallrath L L

Abstract excerpt

Transgenes inserted into the telomeric regions of Drosophila melanogaster chromosomes exhibit position effect variegation (PEV), a mosaic silencing characteristic of euchromatic genes brought into juxtaposition with heterochromatin. Telomeric transgenes on the second and third chromosomes are flanked by telomeric associated sequences (TAS), while fourth chromosome telomeric transgenes are most often associated...

Topics

Animals
Cell Nucleus
Chromatin
Chromosomes
Drosophila Proteins
Drosophila melanogaster
Eye
Female
Gene Expression Regulation
Genes, Insect
Heat-Shock Proteins
Heat-Shock Response
Male
Models, Genetic

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Structure

Mutation

Phenotype

Repetitive Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 10393187
DOI: 10.1093/emboj/18.13.3724
PMCID: PMC1171449

Provenance

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