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Article

Silencing at Drosophila telomeres: nuclear organization and chromatin structure play critical roles.

The EMBO journal - 1 Jul 1999

Cryderman D E, Morris E J, Biessmann H, Elgin S C, Wallrath L L

Abstract excerpt

Transgenes inserted into the telomeric regions of Drosophila melanogaster chromosomes exhibit position effect variegation (PEV), a mosaic silencing characteristic of euchromatic genes brought into juxtaposition with heterochromatin. Telomeric transgenes on the second and third chromosomes are flanked by telomeric associated sequences (TAS), while fourth chromosome telomeric transgenes are most often associated...

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Identifiers

PMID: 10393187
DOI: 10.1093/emboj/18.13.3724
PMCID: PMC1171449

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