Locus specificity determinants in the multifunctional yeast silencing protein Sir2.

doi:10.1093/emboj/19.11.2641

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Article

Locus specificity determinants in the multifunctional yeast silencing protein Sir2.

The EMBO journal - 1 Jun 2000

Cuperus G, Shafaatian R, Shore D

Abstract excerpt

Yeast SIR2, the founding member of a conserved gene family, acts to modulate chromatin structure in three different contexts: silent (HM) mating-type loci, telomeres and rDNA. At HM loci and telomeres, Sir2p forms a complex with Sir3p and Sir4p. However, Sir2p's role in rDNA silencing is Sir3/4 independent, requiring instead an essential nucleolar protein, Net1p. We describe two novel classes of SIR2 mutations...

Topics

Chromatin
Chromosomes, Fungal
DNA, Fungal
DNA, Ribosomal
Fungal Proteins
Gene Silencing
Gene Targeting
Genes, Dominant
Genes, Fungal
Genes, Mating Type, Fungal
Histone Deacetylases
Macromolecular Substances
Mutagenesis
Oncogene Proteins
Phenotype

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Identifiers

PMID: 10835361
DOI: 10.1093/emboj/19.11.2641
PMCID: PMC212746

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Polymerase Chain Reaction

Protein Structure, Tertiary

Saccharomyces cerevisiae