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Article

Locus specificity determinants in the multifunctional yeast silencing protein Sir2.

The EMBO journal - 1 Jun 2000

Cuperus G, Shafaatian R, Shore D

Abstract excerpt

Yeast SIR2, the founding member of a conserved gene family, acts to modulate chromatin structure in three different contexts: silent (HM) mating-type loci, telomeres and rDNA. At HM loci and telomeres, Sir2p forms a complex with Sir3p and Sir4p. However, Sir2p's role in rDNA silencing is Sir3/4 independent, requiring instead an essential nucleolar protein, Net1p. We describe two novel classes of SIR2 mutations...

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Identifiers

PMID: 10835361
DOI: 10.1093/emboj/19.11.2641
PMCID: PMC212746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Locus specificity determinants in the multifunctional yeast silencing protein Sir2.PMID 10835361Read ↗

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