Article
TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Jun 1996
Runge K W, Zakian V A
Abstract excerpt
The DNA-protein complexes at the ends of linear eukaryotic chromosomes are called the telomeres. In Saccharomyces cerevisiae, telomeric DNA consists of a variable length of the short repeated sequence C1-3A. The length of yeast telomeres can be altered by mutation, by changing the levels of telomere binding proteins, or by increasing the amount of C1-3A DNA sequences. Cells bearing the tel1-1 or tel2-1 mutations,...
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