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Article

The conserved core of a human SIR2 homologue functions in yeast silencing.

Molecular biology of the cell - 1 Sept 1999

Sherman J M, Stone E M, Freeman-Cook L L, Brachmann C B, Boeke J D, Pillus L

Abstract excerpt

Silencing is a universal form of transcriptional regulation in which regions of the genome are reversibly inactivated by changes in chromatin structure. Sir2 (Silent Information Regulator) protein is unique among the silencing factors in Saccharomyces cerevisiae because it silences the rDNA as well as the silent mating-type loci and telomeres. Discovery of a gene family of Homologues of Sir Two (HSTs) in...

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Share to Chromosomes, Fungal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

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Identifiers

PMID: 10473645
DOI: 10.1091/mbc.10.9.3045
PMCID: PMC25551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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