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Article

Association of HLA-DQ Heterodimer Residues -18β and β57 With Progression From Islet Autoimmunity to Diabetes in the Diabetes Prevention Trial-Type 1.

Diabetes care - 7 Jul 2022

Zhao Lue Ping, Skyler Jay, Papadopoulos George K, Pugliese Alberto, Najera James Antonio, Bondinas George P, Moustakas Antonis K, Wang Ruihan, Pyo Chul-Woo, Nelson Wyatt C, Geraghty Daniel E, Lernmark Åke

Abstract excerpt

OBJECTIVE: The purpose was to test the hypothesis that the HLA-DQαβ heterodimer structure is related to the progression of islet autoimmunity from asymptomatic to symptomatic type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: Next-generation targeted sequencing was used to genotype HLA-DQA1-B1 class II genes in 670 subjects in the Diabetes Prevention Trial-Type 1 (DPT-1). Coding sequences were translated into DQ...

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Identifiers

PMID: 35621697
DOI: 10.2337/dc21-1628
PMCID: PMC9274226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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