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Complete HLA genotyping of type 1 diabetes patients and controls from Mali reveals both expected and novel disease associations.

HLA - 1 Jan 2024

Noble Janelle A, Besançon Stéphane, Sidibé Assa Traore, Rozemuller Erik H, Rijkers Maaike, Dadkhodaie Fereshte, de Bruin Helma, Kooij Jannetje, Martin Harper R N, Ogle Graham D, Mack Steven J

Abstract excerpt

HLA genotyping was performed on 99 type 1 diabetes (T1D) patients and 200 controls from Mali. Next-generation sequencing of the classical HLA-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, -DQA1, -DQB1, -DPA1, and -DPB1 loci revealed strong T1D association for all loci except HLA-C and -DPA1. Class II association is stronger than class I association, with most observed associations predisposing or protective as expected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38226399
DOI: 10.1111/tan.15319
PMCID: PMC10863981

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