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Article

Genetics of the HLA region in the prediction of type 1 diabetes.

Current diabetes reports - 1 Dec 2011

Noble Janelle A, Valdes Ana M

Abstract excerpt

Type 1 diabetes (T1D) is one of the most widely studied complex genetic disorders, and the genes in HLA are reported to account for approximately 40-50% of the familial aggregation of T1D. The major genetic determinants of this disease are polymorphisms of class II HLA genes encoding DQ and DR. The DR-DQ haplotypes conferring the highest risk are DRB1*03:01-DQA1*05:01-DQB1*02:01 (abbreviated "DR3") and...

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Share to Diabetes Mellitus, Type 1
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

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Share to Immune Cell Function and Interaction

Share to Pancreatic function and diabetes

Source

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Identifiers

PMID: 21912932
DOI: 10.1007/s11892-011-0223-x
PMCID: PMC3233362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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