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Article

Construction of recombinant plasmid harboring APP717 mutation and preliminary study of APP proteolysis.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban - 1 Oct 2007

Li Xiaoqing, Xue Zheng, Zhang Suming

Abstract excerpt

In order to investigate the pathogenesis of Alzheimer disease (AD) and study the enzymatic progress of amyloid precursor protein (APP), the fluorescent eukaryotic expression plasmid of C99 was constructed containing APP717 mutation. The fragment encoding the last 99-aa of APP (which was named C99 containing APP717 mutation), together with the fragment encoding yellow fluorescence protein (which was named YFP)...

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PMID: 18060616
DOI: 10.1007/s11596-007-0502-6

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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