Article
Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein.
Neuroscience bulletin - 1 Apr 2016
Yu You, Li Yinan, Zhang Yan
Abstract excerpt
Alzheimer's disease (AD) is a neurodegenerative disorder in which amyloid β plaques are a pathological characteristic. Little is known about the physiological functions of amyloid β precursor protein (APP). Based on its structure as a type I transmembrane protein, it has been proposed that APP might be a receptor, but so far, no ligand has been reported. In the present study, 9 proteins binding to the...
Topics
- Adaptor Proteins, Signal Transducing
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Gene Library
- HEK293 Cells
- Humans
- Immunoprecipitation
- Luminescent Proteins
- Membrane Proteins
- Mutation