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Article

Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology.

Scientific reports - 29 Feb 2016

Wang Yajie, Wu Fengyi, Pan Haining, Zheng Wenzhong, Feng Chi, Wang Yunfu, Deng Zixin, Wang Lianrong, Luo Jie, Chen Shi

Abstract excerpt

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) deposition in the brain. Aβ plaques are produced through sequential β/γ cleavage of amyloid precursor protein (APP), of which there are three main APP isoforms: APP695, APP751 and APP770. KPI-APPs (APP751 and APP770) are known to be elevated in AD, but the reason remains unclear. Transcription activator-like (TAL) effector nucleases (TALENs) induce...

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Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26924205
DOI: 10.1038/srep22244
PMCID: PMC4770288

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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