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Article

Cellular cholesterol loss by DHCR24 knockdown leads to Aβ production by changing APP intracellular localization

1 Apr 2023

Abstract excerpt

For the past 20 years, the majority of cell culture studies reported that increasing cholesterol level increases amyloid-β (Aβ) production. Conversely, other studies and genetic evidences support that cellular cholesterol loss leads to Aβ generation. As a highly controversial issue in Alzheimer's disease pathogenesis, the apparent contradiction prompted us to again explore the role of cellular cholesterol in Aβ...

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PMID: 37011864
DOI: 10.1016/j.jlr.2023.100367

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