Amyloid precursor protein gene mutated at Swedish 670/671 sites in vitro induces changed expression of nicotinic acetylcholine receptors and neurotoxicity.

Abstract excerpt

In order to investigate the influence of amyloid precursor protein (APP) over-expression on the levels of nicotinic acetylcholine receptors (nAChRs), the pCDNA 3.0 carrying the Swedish 670/671 APP double mutation (APP(SWE)) gene was transfected into human neuroblastoma (SH-SY5Y) cells and primary culture of rat hippocampal neurons. The mRNA level of APP, and nAChR α3, α4 and α7 subunits were detected by real-time...

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