Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells.

doi:10.1002/jnr.490400215

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Article

Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells.

Journal of neuroscience research - 1 Feb 1995

Zhao B, Sisodia S S, Kusiak J W

Abstract excerpt

Altered proteolysis of the amyloid precursor protein (APP) may play an important role in Alzheimer disease (AD). To better understand the role of mutant APP in the pathogenesis of the disease, we stably overexpressed the mutant APP717F approximately twofold vs. the endogenous wild-type gene in se...

Topics

Alzheimer Disease
Amyloid beta-Protein Precursor
Animals
Antibodies
Blotting, Western
Cells, Cultured
Endothelium
Gene Expression
Humans
Lysosomes
Mutation
Neurons
Precipitin Tests
Rats

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