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Article

Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells.

Journal of neuroscience research - 1 Feb 1995

Zhao B, Sisodia S S, Kusiak J W

Abstract excerpt

Altered proteolysis of the amyloid precursor protein (APP) may play an important role in Alzheimer disease (AD). To better understand the role of mutant APP in the pathogenesis of the disease, we stably overexpressed the mutant APP717F approximately twofold vs. the endogenous wild-type gene in several cell types. The processing of APP was examined by Western blot analysis and immunoprecipitation. We observed...

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Source

Identifiers

PMID: 7745619
DOI: 10.1002/jnr.490400215

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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