Article

Direct imaging of APP proteolysis in living cells

2017-02-15

Abstract excerpt

It is now widely accepted that oligomers consisting of Aβ peptide are the cytotoxic species contributing mostly to the development of Alzheimer’s disease. Aβ peptide production results from the specific proteolytic processing of the amyloid precursor protein (APP). Deciphering the factors governing the activity of the secretases responsible for the cleavage of APP is still a critical issue. Kits available commerci...

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Literature Corpus work: 53d3e127-73c5-5422-ba92-06dadcf59646
DOI: 10.7287/peerj.preprints.2804v1

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