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Article

Cis-combination of the classic per(S) and per(L) mutations results in arrhythmic Drosophila with ectopic accumulation of hyperphosphorylated PERIOD protein.

Journal of biological rhythms - 1 Dec 2007

Ko Hyuk Wan, DiMassa Suzanne, Kim Eun Young, Bae Kiho, Edery Isaac

Abstract excerpt

The 1st circadian "clock" gene identified was the X-linked period (per) gene in Drosophila melanogaster. In the pioneering initial report, Konopka and Benzer (1971) characterized 3 alleles of per that shortened (per (S); approximately 19 h), lengthened (per (L); approximately 29 h), or abolished (per (0)) circadian behavioral rhythms. They also showed that transheterozygotes carrying the per (S) and per (L)...

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PMID: 18057324
DOI: 10.1177/0748730407306929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Cis-combination of the classic per(S) and per(L) mutations results in arrhythmic Drosophila with ectopic accumulation of hyperphosphorylated PERIOD protein.PMID 18057324Read ↗

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