Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cis-combination of the classic per(S) and per(L) mutations results in arrhythmic Drosophila with ectopic accumulation of hyperphosphorylated PERIOD protein.

Journal of biological rhythms - 1 Dec 2007

Ko Hyuk Wan, DiMassa Suzanne, Kim Eun Young, Bae Kiho, Edery Isaac

Abstract excerpt

The 1st circadian "clock" gene identified was the X-linked period (per) gene in Drosophila melanogaster. In the pioneering initial report, Konopka and Benzer (1971) characterized 3 alleles of per that shortened (per (S); approximately 19 h), lengthened (per (L); approximately 29 h), or abolished...

Topics

Animals
Animals, Genetically Modified
Brain
Cell Culture Techniques
Circadian Rhythm
Drosophila
Drosophila Proteins
Gene Expression Regulation
Homeostasis
Mutation
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Period Circadian Proteins

Phosphorylation

RNA

Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 18057324
DOI: 10.1177/0748730407306929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-18057324-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cis-combination of the classic per(S) and per(L) mutations results in arrhythmic Drosophila with ectopic accumulation of hyperphosphorylated PERIOD protein.PMID 18057324Read ↗

Molecular and behavioral analysis of four period mutants in Drosophila melanogaster encompassing extreme short, novel long, and unorthodox arrhythmic types.Semantic proximity Read ↗

The analysis of new short-period circadian rhythm mutants suggests features of D. melanogaster period gene function.Semantic proximity Read ↗

Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila.Semantic proximity Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.Semantic proximity Read ↗

Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock.Semantic proximity Read ↗

The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression.Semantic proximity Read ↗

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Semantic proximity Read ↗

New short period mutations of the Drosophila clock gene per.Semantic proximity Read ↗

Temporal phosphorylation of the Drosophila period protein.Semantic proximity Read ↗

Endogenous circadian reporters reveal critical consequences of diverse novel mutations in clock genesSemantic proximity Read ↗

Constitutive expression of the <i>Period1</i> gene impairs behavioral and molecular circadian rhythmsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.