Article
The analysis of new short-period circadian rhythm mutants suggests features of D. melanogaster period gene function.
Journal of neurogenetics - 1 May 1992
Rutila J E, Edery I, Hall J C, Rosbash M
Abstract excerpt
A number of new period gene (per) mutants were generated by in vitro mutagenesis and germ line transformation. Missense mutations were made at amino acid 589, which is altered in the 19 h short-period (per(s)) mutant, and insertion mutations were generated with peptides commonly used for epitope tagging. Most of these new per mutants had short behavioral rhythms. Flies with heteroallelic combinations of these new...
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