Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement.

Abstract excerpt

Enterovirus 71 (EV71) is a major cause of hand-foot-and-mouth disease. EV71 infection occasionally associates with severe neurological sequelae such as brainstem encephalitis or poliovirus-like paralysis. We demonstrated that mouse-adapted strain increases infectivity, resulting in higher cytotoxicity of neuron cells and mortality to neonatal mice than a non-adapted strain. Results pointed to EV71 capsid region...

Topics

• Amino Acid Sequence
• Amino Acid Substitution
• Animals
• Apoptosis
• Capsid Proteins
• Chlorocebus aethiops
• Enterovirus A, Human
• Enterovirus Infections
• Genetic Variation
• Hand, Foot and Mouth Disease
• Mice
• Mutant Proteins
• Mutation
• RNA, Viral