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Vpr.A3A Chimera Inhibits HIV Replication

6 Dec 2007

Abstract excerpt

Several APOBEC3 proteins (A3F and A3G), that are cytidine deaminases restrict human immunodeficiency virus (HIV) replication in the absence of the viral infectivity factor (Vif) protein. However, Vif leads to their degradation and counteracts their effects. Another member, A3A, restricts some retrotransposons and another virus but not HIV. We reasoned that this failure was due to the lack of appropriate...

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PMID: 18057006
DOI: 10.1074/jbc.m706436200

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