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Article

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics

1 Jan 2010

Abstract excerpt

Restriction factors are natural cellular proteins that defend individual cells from viral infection. These factors include the APOBEC3 family of DNA cytidine deaminases, which restrict the infectivity of HIV-1 by hypermutating viral cDNA and inhibiting reverse transcription and integration. HIV-1 thwarts this restriction activity through its accessory protein virion infectivity factor (Vif), which uses multiple...

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PMID: 20096141
DOI: 10.1017/s1462399409001343

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