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Article

Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.

Cell - 11 Jul 2003

Mariani Roberto, Chen Darlene, Schröfelbauer Bärbel, Navarro Francisco, König Renate, Bollman Brooke, Münk Carsten, Nymark-McMahon Henrietta, Landau Nathaniel R

Abstract excerpt

The HIV-1 accessory protein Vif (virion infectivity factor) is required for the production of infectious virions by CD4(+) lymphocytes. Vif facilitates particle infectivity by blocking the inhibitory activity of APOBEC3G (CEM15), a virion-encapsidated cellular protein that deaminates minus-strand reverse transcript cytosines to uracils. We report that HIV-1 Vif forms a complex with human APOBEC3G that prevents...

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Identifiers

PMID: 12859895
DOI: 10.1016/s0092-8674(03)00515-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.PMID 12859895Read ↗

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