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Article

Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation.

Cancer research - 1 Dec 2007

Sankaran Satish, Crone Donna E, Palazzo Robert E, Parvin Jeffrey D

Abstract excerpt

Breast cancer-associated gene 1 (BRCA1) regulates the duplication and the function of centrosomes in breast cells. We have previously shown that BRCA1 ubiquitin ligase activity directly inhibits centrosome-dependent microtubule nucleation. However, there is a paradox because centrosome microtubule nucleation potential is highest during mitosis, a phase when BRCA1 is most abundant at the centrosome. In this study,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18056443
DOI: 10.1158/0008-5472.CAN-07-2578

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation.PMID 18056443Read ↗

Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination.Semantic proximity Read ↗

Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase.Semantic proximity Read ↗

Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase.Semantic proximity Read ↗

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.Semantic proximity Read ↗

Centrosome amplification drives chromosomal instability in breast tumor development.Semantic proximity Read ↗

CDC25B Involvement in the Centrosome Duplication Cycle and in Microtubule NucleationSemantic proximity Read ↗

Control of centrin stability by Aurora A.Semantic proximity Read ↗

BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells.Semantic proximity Read ↗

Auto-inhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defectsSemantic proximity Read ↗

Mps1 as a link between centrosomes and genomic instability.Semantic proximity Read ↗

Dysfunctional BRCA1 is only indirectly linked to multiple centrosomes.Semantic proximity Read ↗

G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cellsSemantic proximity Read ↗

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