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Article

Mps1 as a link between centrosomes and genomic instability.

Environmental and molecular mutagenesis - 1 Oct 2009

Kasbek Christopher, Yang Ching-Hui, Fisk Harold A

Abstract excerpt

Centrosomes are microtubule-organizing centers that must be precisely duplicated before mitosis. Centrosomes regulate mitotic spindle assembly, and the presence of excess centrosomes leads to the production of aberrant mitotic spindles which generate chromosome segregation errors. Many human tumors possess excess centrosomes that lead to the production of abnormal spindles in situ. In some tumors, these extra...

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Identifiers

PMID: 19274768
DOI: 10.1002/em.20476
PMCID: PMC2760674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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