Article
Centrosome amplification drives chromosomal instability in breast tumor development.
Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002
Lingle Wilma L, Barrett Susan L, Negron Vivian C, D'Assoro Antonino B, Boeneman Kelly, Liu Wanguo, Whitehead Clark M, Reynolds Carol, Salisbury Jeffrey L
Abstract excerpt
Earlier studies of invasive breast tumors have shown that 60-80% are aneuploid and approximately 80% exhibit amplified centrosomes. In this study, we investigated the relationship of centrosome amplification with aneuploidy, chromosomal instability, p53 mutation, and loss of differentiation in human breast tumors. Twenty invasive breast tumors and seven normal breast tissues were analyzed by fluorescence in situ...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.