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Article

Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination.

Molecular and cellular biology - 1 Oct 2005

Sankaran Satish, Starita Lea M, Groen Aaron C, Ko Min Ji, Parvin Jeffrey D

Abstract excerpt

In this study we find that the function of BRCA1 inhibits the microtubule nucleation function of centrosomes. In particular, cells in early S phase have quiescent centrosomes due to BRCA1 activity, which inhibits the association of gamma-tubulin with centrosomes. We find that modification of either of two specific lysine residues (Lys-48 and Lys-344) of gamma-tubulin, a known substrate for BRCA1-dependent...

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Identifiers

PMID: 16166645
DOI: 10.1128/MCB.25.19.8656-8668.2005
PMCID: PMC1265743

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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