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Article

Dysfunctional BRCA1 is only indirectly linked to multiple centrosomes.

Oncogene - 17 Nov 2005

Hut Henderika M J, Rembacz Krzysztof P, van Waarde Maria A W H, Lemstra Willy, van Cappellen Wiggert A, Kampinga Harm H, Sibon Ody C M

Abstract excerpt

A remarkable and yet unexplained phenomenon in cancer cells is the presence of multiple centrosomes, organelles required for normal cell division. Previously, it was demonstrated that the tumor suppressor BRCA1 is a component of centrosomes. This observation led to the hypothesis that defective B...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16205648
DOI: 10.1038/sj.onc.1208859

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16205648-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Dysfunctional BRCA1 is only indirectly linked to multiple centrosomes.PMID 16205648Read ↗

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Centrosome – a promising anti-cancer targetSemantic proximity Read ↗

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Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cellsSemantic proximity Read ↗

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The centrosomal FOP protein is required for cell cycle progression and survival.Semantic proximity Read ↗

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Origins and consequences of centrosome aberrations in human cancersSemantic proximity Read ↗

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