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Article

BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells.

Oncotarget - 16 May 2017

He Zhengcheng, Kannan Nagarajan, Nemirovsky Oksana, Chen Helen, Connell Marisa, Taylor Brian, Jiang Jihong, Pilarski Linda M, Fleisch Markus C, Niederacher Dieter, Pujana Miguel Angel, Eaves Connie J, Maxwell Christopher A

Abstract excerpt

BRCA1 deficiency may perturb the differentiation hierarchy present in the normal mammary gland and is associated with the genesis of breast cancers that are genomically unstable and typically display a basal-like transcriptome. Oriented cell division is a mechanism known to regulate cell fates and to restrict tumor formation. We now show that the cell division axis is altered following shRNA-mediated BRCA1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28427147
DOI: 10.18632/oncotarget.15688
PMCID: PMC5464802

Genes

BRCA1
CDH1
HMMR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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