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Article

Control of centrin stability by Aurora A.

PloS one - 1 Jan 2011

Lukasiewicz Kara B, Greenwood Tammy M, Negron Vivian C, Bruzek Amy K, Salisbury Jeffrey L, Lingle Wilma L

Abstract excerpt

Aurora A is an oncogenic serine/threonine kinase which can cause cell transformation and centrosome amplification when over-expressed. Human breast tumors show excess Aurora A and phospho-centrin in amplified centrosomes. Here, we show that Aurora A mediates the phosphorylation of and localizes with centrin at the centrosome, with both proteins reaching maximum abundance from prophase through metaphase, followed...

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Share to Anaphase-Promoting Complex-Cyclosome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21731694
DOI: 10.1371/journal.pone.0021291
PMCID: PMC3121746

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APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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