Article
Glutathione S-transferase omega 1 and omega 2 pharmacogenomics.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jul 2006
Mukherjee Baidehi, Salavaggione Oreste E, Pelleymounter Linda L, Moon Irene, Eckloff Bruce W, Schaid Daniel J, Wieben Eric D, Weinshilboum Richard M
Abstract excerpt
Glutathione S-transferase omega 1 and omega 2 (GSTO1 and GSTO2) catalyze monomethyl arsenate reduction, the rate-limiting reaction in arsenic biotransformation. As a step toward pharmacogenomic studies of these phase II enzymes, we resequenced human GSTO1 and GSTO2 using DNA samples from four ethnic groups. We identified 31 and 66 polymorphisms in GSTO1 and GSTO2, respectively, with four nonsynonymous-coding...
Topics
- Black or African American
- Animals
- Arsenic
- Asian
- COS Cells
- Chlorocebus aethiops
- Enzyme Stability
- Gene Expression Regulation, Enzymologic
- Gene Frequency
- Glutathione Transferase
- Haplotypes
- Humans
- Linkage Disequilibrium