Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glutathione S-transferase omega 1 and omega 2 pharmacogenomics.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jul 2006

Mukherjee Baidehi, Salavaggione Oreste E, Pelleymounter Linda L, Moon Irene, Eckloff Bruce W, Schaid Daniel J, Wieben Eric D, Weinshilboum Richard M

Abstract excerpt

Glutathione S-transferase omega 1 and omega 2 (GSTO1 and GSTO2) catalyze monomethyl arsenate reduction, the rate-limiting reaction in arsenic biotransformation. As a step toward pharmacogenomic studies of these phase II enzymes, we resequenced human GSTO1 and GSTO2 using DNA samples from four ethnic groups. We identified 31 and 66 polymorphisms in GSTO1 and GSTO2, respectively, with four nonsynonymous-coding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arsenic
Share to Asian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Black or African American

Share to Chlorocebus aethiops

Share to COS Cells

Share to Enzyme Stability

Share to Gene Expression Regulation, Enzymologic

Share to Mexican Americans

Source

Identifiers

PMID: 16638819
DOI: 10.1124/dmd.106.009613

Genes

GSTO1
GSTO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutathione S-transferase omega 1 and omega 2 pharmacogenomics.PMID 16638819Read ↗

Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases.Semantic proximity Read ↗

Glutathione S-transferase T1 and M1: gene sequence variation and functional genomics.Semantic proximity Read ↗

Glutathione s-transferase p1: gene sequence variation and functional genomic studies.Semantic proximity Read ↗

Glutathione S-transferase polymorphisms: cancer incidence and therapy.Semantic proximity Read ↗

Worldwide Systematic Review of GSTM1 and GSTT1 Null Genotypes by Continent, Ethnicity, and Therapeutic Area.Semantic proximity Read ↗

Functional compensation of glutathione S-transferase M1 (GSTM1) null by another GST superfamily member, GSTM2.Semantic proximity Read ↗

Sulfotransferase genetic variation: from cancer risk to treatment response.Semantic proximity Read ↗

Human sulfotransferase SULT2A1 pharmacogenetics: genotype-to-phenotype studies.Semantic proximity Read ↗

Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics.Semantic proximity Read ↗

Genetic variability of glutathione S-transferase enzymes in human populations: functional inter-ethnic differences in detoxification systems.Semantic proximity Read ↗

Polymorphism and transcriptional regulation of GSTP1 in cancer and other human diseases.Semantic proximity Read ↗

Resequencing the sulfotransferase SULT1 gene provides new insights, while illuminating challenges that lie ahead for pharmacogenomics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.