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Article

Polymorphism and transcriptional regulation of GSTP1 in cancer and other human diseases.

International journal of biological macromolecules - 1 Feb 2026

Zeng Qi-Ran, Du Xiao-Shuai, Zhao Ruo-Xi, Yang Dian, Yang Zhi-Yuan, Liang Yang, Yu Hai-Fan

Abstract excerpt

Glutathione S-transferase P1 (GSTP1) is a crucial phase II metabolic enzyme in humans, playing an indispensable role in protein glutathionylation, antioxidant defense, and cellular metabolic detoxification. Additionally, GSTP1 exhibits multiple genetic polymorphisms that are closely associated with susceptibility to various cancers and diseases. Although the associations of GSTP1 with cancer drug resistance,...

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Source

Identifiers

PMID: 41619888
DOI: 10.1016/j.ijbiomac.2026.150588

Genes

GSTP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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