Article
Functional compensation of glutathione S-transferase M1 (GSTM1) null by another GST superfamily member, GSTM2.
Scientific reports - 1 Jan 2013
Bhattacharjee Pritha, Paul Somnath, Banerjee Mayukh, Patra Deblina, Banerjee Priyam, Ghoshal Nanda, Bandyopadhyay Arun, Giri Ashok K
Abstract excerpt
The gene for glutathione-S-transferase (GST) M1 (GSTM1), a member of the GST-superfamily, is widely studied in cancer risk with regard to the homozygous deletion of the gene (GSTM1 null), leading to a lack of corresponding enzymatic activity. Many of these studies have reported inconsistent findings regarding its association with cancer risk. Therefore, we employed in silico, in vitro, and in vivo approaches to...
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