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Article

Persistent transcription of a nonintegrating mutant of simian immunodeficiency virus in rhesus macrophages.

Virology - 15 Mar 2008

Zheng Yanfang, Ourmanov Ilnour, Hirsch Vanessa M

Abstract excerpt

A nonintegrating mutant, SIVsmD116N, was derived from the infectious pathogenic SIVsmE543-3 clone by introducing an Asp (D) to Asn (N) mutation into the catalytic domain of integrase. Although SIVsmD116N generated all viral proteins following transfection, cell-free virus did not productively infect CEMx174 cells, macaque peripheral blood mononuclear cells (PBMCs) or monocyte-derived macrophages (MDM). Viral DNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18054062
DOI: 10.1016/j.virol.2007.11.002
PMCID: PMC2350229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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