Article
The tyrosine-17 residue of Nef in SIVsmmPBj14 is required for acute pathogenesis and contributes to replication in macrophages.
Virology - 10 May 1998
Saucier M, Hodge S, Dewhurst S, Gibson T, Gibson J P, McClure H M, Novembre F J
Abstract excerpt
The variant simian immunodeficiency virus termed SIVsmmPBj14 induces a rapidly fatal disease in pig-tailed macaques. The acute pathogenic effects of this virus appear to be associated with at least two in vitro characteristics: the ability to induce lymphocyte proliferation; and the ability to re...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Primers
- Gene Products, nef
- Genes, nef
- Genetic Variation
- In Vitro Techniques
- Lymphocyte Activation
- Macaca nemestrina
- Macrophages
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus
- Tyrosine
- Virus Replication