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Article

The vpx gene of simian immunodeficiency virus facilitates efficient viral replication in fresh lymphocytes and macrophage

1 Sept 1991

Abstract excerpt

vpx is a unique open reading frame found in simian immunodeficiency virus (SIV) and human immunodeficiency virus type 2 (HIV-2) but not in HIV-1. It encodes a 12- to 16-kDa virion-associated protein. Although vpx is dispensable for viral replication in several established human lymphocyte cell lines, there is no consensus regarding whether this gene is required for efficient viral replication in freshly isolated...

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PMID: 1714525
DOI: 10.1128/jvi.65.9.5088-5091.1991

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The vpx gene of simian immunodeficiency virus facilitates efficient viral replication in fresh lymphocytes and macrophagePMID 1714525Read ↗

Evidence for an Activation Domain at the Amino Terminus of Simian Immunodeficiency Virus VpxSemantic proximity Read ↗

Vpx Is Critical for Reverse Transcription of the Human Immunodeficiency Virus Type 2 Genome in MacrophagesSemantic proximity Read ↗

The Human Immunodeficiency Virus Type 2 Vpx Protein Usurps the CUL4A-DDB1 DCAF1 Ubiquitin Ligase To Overcome a Postentry Block in Macrophage InfectionSemantic proximity Read ↗

Characterization of Simian Immunodeficiency Virus SIV <sub>SM</sub> /Human Immunodeficiency Virus Type 2 Vpx Function in Human Myeloid CellsSemantic proximity Read ↗

Limelight on two HIV/SIV accessory proteins in macrophage infection: Is Vpx overshadowing Vpr?Semantic proximity Read ↗

Human immunodeficiency virus Vpx is required for the early phase of replication in peripheral blood mononuclear cells.Semantic proximity Read ↗

Distinct Effects in Primary Macrophages and Lymphocytes of the Human Immunodeficiency Virus Type 1 Accessory Genes vpr, vpu, and nef: Mutational Analysis of a Primary HIV-1 IsolateSemantic proximity Read ↗

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HIV-1 Vprâ€”a still â€œenigmatic multitaskerâ€Semantic proximity Read ↗

Illuminating the Role of Vpr in HIV Infection of Myeloid CellsSemantic proximity Read ↗

Effects of vpu start-codon mutations on human immunodeficiency virus type 1 replication in macrophages.Semantic proximity Read ↗

Progression to AIDS in the absence of a gene for vpr or vpx.Semantic proximity Read ↗

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