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Article

Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1

1 May 1995

Abstract excerpt

Certain human immunodeficiency virus type 1 (HIV-1) isolates are able to productively infect nondividing cells of the monocyte/macrophage lineage. We have used a molecular genetic approach to construct two different HIV-1 integrase mutants that were studied in the context of an infectious, macrophage-tropic HIV-1 molecular clone. One mutant, HIV-1 delta D(35)E, containing a 37-residue deletion within the central,...

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Identifiers

PMID: 7707554
DOI: 10.1128/jvi.69.5.3216-3219.1995

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