Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of deletion mutants of simian immunodeficiency virus incapable of proviral integration.

Journal of virology - 1 Jan 1992

Prakash K, Ranganathan P N, Mettus R, Reddy P, Srinivasan A, Plotkin S

Abstract excerpt

Deletion mutants of simian immunodeficiency virus (SIVmac) which were unable to integrate into host cells were generated by removing a portion of the integrase (IN) domain of the pol gene. The resulting plasmid was transfected into HUT-78 and human rhabdomyosarcoma cells. In comparison with the parental plasmid DNA transfected in parallel, the deletion mutant was found to direct efficient production of virus in...

Topics

Base Sequence
DNA, Viral
Humans
Kinetics
Molecular Sequence Data
Mutation
Plasmids
Polymerase Chain Reaction
Simian Immunodeficiency Virus
Transfection
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Integration

Source

Open in PubMed Open full text

Identifiers

PMID: 1727479
DOI: 10.1128/JVI.66.1.167-171.1992
PMCID: PMC238272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1727479-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of deletion mutants of simian immunodeficiency virus incapable of proviral integration.PMID 1727479Read ↗

Identification of critical amino acid residues in human immunodeficiency virus type 1 IN required for efficient proviral DNA formation at steps prior to integration in dividing and nondividing cells.Semantic proximity Read ↗

Persistent transcription of a nonintegrating mutant of simian immunodeficiency virus in rhesus macrophages.Semantic proximity Read ↗

Mutations in the catalytic core or the C-terminus of murine leukemia virus (MLV) integrase disrupt virion infectivity and exert diverse effects on reverse transcription.Semantic proximity Read ↗

Reversion of the lethal phenotype of an HIV-1 integrase mutant virus by overexpression of the same integrase mutant protein.Semantic proximity Read ↗

The Cell Cycle Independence of HIV Infections Is Not Determined by Known Karyophilic Viral ElementsSemantic proximity Read ↗

Simian virus 40-based replication of catalytically inactive human immunodeficiency virus type 1 integrase mutants in nonpermissive T cells and monocyte-derived macrophages.Semantic proximity Read ↗

Moloney murine leukemia virus integrase protein augments viral DNA synthesis in infected cells.Semantic proximity Read ↗

Genetic characterization of simian immunodeficiency virus isolated from an African mandrill.Semantic proximity Read ↗

Genetic Analyses of Conserved Residues in the Carboxyl-Terminal Domain of Human Immunodeficiency Virus Type 1 IntegraseSemantic proximity Read ↗

Changes in the mechanism of DNA integration in vitro induced by base substitutions in the HIV-1 U5 and U3 terminal sequences.Semantic proximity Read ↗

Integration is essential for efficient gene expression of human immunodeficiency virus type 1Semantic proximity Read ↗

Analysis of mutations in the integration function of Moloney murine leukemia virus: effects on DNA binding and cutting.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.