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Article

Generation of deletion mutants of simian immunodeficiency virus incapable of proviral integration.

Journal of virology - 1 Jan 1992

Prakash K, Ranganathan P N, Mettus R, Reddy P, Srinivasan A, Plotkin S

Abstract excerpt

Deletion mutants of simian immunodeficiency virus (SIVmac) which were unable to integrate into host cells were generated by removing a portion of the integrase (IN) domain of the pol gene. The resulting plasmid was transfected into HUT-78 and human rhabdomyosarcoma cells. In comparison with the parental plasmid DNA transfected in parallel, the deletion mutant was found to direct efficient production of virus in...

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Identifiers

PMID: 1727479
DOI: 10.1128/JVI.66.1.167-171.1992
PMCID: PMC238272

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Source receipt: pubmed, retrieved 7 Sept 2026.

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