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Article

Multiple viral determinants contribute to pathogenicity of the acutely lethal simian immunodeficiency virus SIVsmmPBj variant.

Journal of virology - 1 May 1993

Novembre F J, Johnson P R, Lewis M G, Anderson D C, Klumpp S, McClure H M, Hirsch V M

Abstract excerpt

Simian immunodeficiency virus (SIV) induces an immunodeficiency syndrome similar to human AIDS. Although the disease course of SIV-induced immunodeficiency is generally measured in months to years, a disease syndrome that results in death in 5 to 14 days has been described in pig-tailed macaques infected with the SIVsmmPBj (PBj) strain. The purpose of this study was to derive an acutely lethal PBj molecular clone...

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Identifiers

PMID: 8474153
DOI: 10.1128/JVI.67.5.2466-2474.1993
PMCID: PMC237565

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