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Article

Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14.

Journal of virology - 1 Dec 1994

Dollard S C, Gummuluru S, Tsang S, Fultz P N, Dewhurst S

Abstract excerpt

Infection with a variant of simian immunodeficiency virus, SIVsmmPBj14, leads to severe acute disease in macaques. This study was designed to investigate the functional significance of previously described mutations in the viral long terminal repeat (LTR) and to elucidate their contribution to the unique phenotype of SIVsmmPBj14. LTR-directed transcription was measured by using luciferase reporter constructs that...

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Identifiers

PMID: 7966569
DOI: 10.1128/JVI.68.12.7800-7809.1994
PMCID: PMC237241

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