Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14.

doi:10.1128/JVI.68.12.7800-7809.1994

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Article

Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14.

Journal of virology - 1 Dec 1994

Dollard S C, Gummuluru S, Tsang S, Fultz P N, Dewhurst S

Abstract excerpt

Infection with a variant of simian immunodeficiency virus, SIVsmmPBj14, leads to severe acute disease in macaques. This study was designed to investigate the functional significance of previously described mutations in the viral long terminal repeat (LTR) and to elucidate their contribution to th...

Topics

Animals
Base Sequence
Cell Line
Cells, Cultured
Gene Expression
Genetic Variation
Humans
Interleukin-2
Kinetics
Lymphocytes
Macaca fascicularis
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

NF-kappa B

Pan troglodytes

Phenotype

Repetitive Sequences, Nucleic Acid

Simian Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 7966569
DOI: 10.1128/JVI.68.12.7800-7809.1994
PMCID: PMC237241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7966569-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14.PMID 7966569Read ↗

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The tyrosine-17 residue of Nef in SIVsmmPBj14 is required for acute pathogenesis and contributes to replication in macrophages.Semantic proximity Read ↗

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