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Generation of CD8+T-Cell Responses by a Recombinant NonpathogenicMycobacterium smegmatisVaccine Vector Expressing Human Immunodeficiency Virus Type 1 Env

26 Jan 2006

Abstract excerpt

Because the vaccine vectors currently being evaluated in human populations all have significant limitations in their immunogenicity, novel vaccine strategies are needed for the elicitation of cell-mediated immunity. The nonpathogenic, rapidly growing mycobacterium Mycobacterium smegmatis was engineered as a vector expressing full-length human immunodeficiency virus type 1 (HIV-1) HXBc2 envelope protein....

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PMID: 16439521
DOI: 10.1128/jvi.80.4.1645-1652.2006

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