Article
Hereditary diffuse gastric cancer: association with lobular breast cancer.
Familial cancer - 1 Jan 2008
Schrader Kasmintan A, Masciari Serena, Boyd Niki, Wiyrick Sara, Kaurah Pardeep, Senz Janine, Burke Wylie, Lynch Henry T, Garber Judy E, Huntsman David G
Abstract excerpt
Hereditary diffuse gastric cancer (HDGC) has been shown to be caused by germline mutations in the gene CDH1 located at 16q22.1, which encodes the cell-cell adhesion molecule, E-cadherin. Not only does loss of expression of E-cadherin account for the morphologic differences between intestinal and diffuse gastric cancer (DGC) variants, but it also appears to lead to distinct cellular features which appear to be...
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