Hereditary diffuse gastric cancer: association with lobular breast cancer.

doi:10.1007/s10689-007-9172-6

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Article

Hereditary diffuse gastric cancer: association with lobular breast cancer.

Familial cancer - 1 Jan 2008

Schrader Kasmintan A, Masciari Serena, Boyd Niki, Wiyrick Sara, Kaurah Pardeep, Senz Janine, Burke Wylie, Lynch Henry T, Garber Judy E, Huntsman David G

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) has been shown to be caused by germline mutations in the gene CDH1 located at 16q22.1, which encodes the cell-cell adhesion molecule, E-cadherin. Not only does loss of expression of E-cadherin account for the morphologic differences between intestinal and diffuse gastric cancer (DGC) variants, but it also appears to lead to distinct cellular features which appear to be...

Topics

Antigens, CD
Breast Neoplasms
Cadherins
Carcinoma, Lobular
Female
Gastrectomy
Gene Expression Regulation, Neoplastic
Genetic Counseling
Genetic Predisposition to Disease
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mass Screening

Middle Aged

Neoplasms, Multiple Primary

Risk

Stomach Neoplasms

Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 18046629
DOI: 10.1007/s10689-007-9172-6
PMCID: PMC2253650

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18046629-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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