Article
Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria.
Kidney international - 1 Feb 2008
van den Hoven M J, Wijnhoven T J, Li J-P, Zcharia E, Dijkman H B, Wismans R G, Rops A L, Lensen J F, van den Heuvel L P, van Kuppevelt T H, Vlodavsky I, Berden J H M, van der Vlag J
Abstract excerpt
Heparan sulfate in the glomerular basement membrane has been considered crucial for charge-selective filtration. In many proteinuric diseases, increased glomerular expression of heparanase is associated with decreased heparan sulfate. Here, we used mice overexpressing heparanase and evaluated the expression of different heparan sulfate domains in the kidney and other tissues measured with anti-heparan sulfate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.